François Bertaux

quantitative biology


I am an engineer and mathematician turned quantitative biologist.

In April 2018, I joined Institut Pasteur in Paris as a research engineer. I am part of the InBio team, led by Gregory Batt. We try to invent new ways of investigating cellular processes, using optogenetic control, optimal experimental design, and some lab automation when it makes sense.

Previously, I did a postdoc at Imperial College London with Sam Marguerat and Vahid Shahrezaei. I worked with fission yeast (S. pombe), a nice model organism that we use to address fundamental questions about the interplay between growth, cell size and gene expression. I was combining experiments (continuous culture, genetic engineering, single-cell microscopy) with mathematical and computational modeling.

Before that, my PhD work was purely computational, yet highly data-driven. I was then at Inria, Paris working with Dirk Drasdo and Gregory Batt. One main topic of my PhD work was to investigate in-silico the molecular mechanisms behind the resistance of cancer cells to the death ligand TRAIL. To do that, I developped a cell-based (each cell is represented individually) multi-scale (cellular decisions are controlled by biochemical reaction pathways simulated in each cell) approach to model the dynamics of cell populations.

I am very enthusiastic about the automation of biological experiments (at all scales of cost and throughput). Together with a formal, model-based representation of cells and experiments, I think we have a winning combination for accelerating quantitative biology.

cells, real and virtual

Contact: Email. Also on ResearchGate, LinkedIn, twitter.